Effectiveness of non-invasive ventilation (NIV) in patients with COPD in the ICU, on the ward, and in A&E departments
| Setting | Baseline data pH | ETI or “surrogate” | Mortality | Mode plus settings (cm H2O) and use on day 1 (when stated) | |
|---|---|---|---|---|---|
| ETI=endotracheal intubation; PSV=pressure support ventilation. | |||||
| ICU studies | |||||
| Brochard et al28 | ICU | 7.28 v 7.27 | 11/43 v 31/42 | 4/43 v 12/42 | PSV 20 for at least 6 hours/day |
| Celikel et al30 | ICU | 7.27 v 7.28 | 1/16 v 6/15 | 0/15 v 1/15 | PSV 15.4 for mean of 26.7 hours |
| Kramer et al29 | ICU | 7.29 v 7.27 | 9% v 67% | IPAP 11.3, EPAP 2.6 for 20.1 hours | |
| Martin et al31 | ICU | 7.27 v 7.28 | 25% v 45%; 5.26 v 15.6/100 ICU days | 8% v 9% | IPAP 11, EPAP 5.7 |
| Ward studies | |||||
| Angus et al33 | Ward | 7.31 v 7.30 | 0/9 v 5/8 | 0/9 v 3/8 | IPAP 14–18 |
| Bardi et al35 | Ward | 7.36 v 7.39 | 1/15 v 2/15 | 0/15 v 1/15 | IPAP 13, EPAP 3 |
| Bott et al32 | Ward | 7.35 | 0/30 v 5/30 | 3/30 v 9/30 | Volume cycled ventilators for 7.63 hours |
| Plant et al34 | Ward | 7.32 v 7.31 | 15% v 27% | 10% v 20% | IPAP 10–20, EPAP 5 for median of 8 hours |
| A&E studies | |||||
| Barbe et al36 | A&E and ward | 7.33 | 0/12 v 0/12 | 0/12 v 0/12 | IPAP 14.8, EPAP 5 for 2 × 3 hour sessions per day |
| Wood et al37 | A&E | 7.35 v 7.34 | See text | See text | Subgroup COPD (n=6 of which 2 NIV, 4 control) |