Reference | N | Study duration (weeks) | Doses of FP used (µg/day) | Device | FEV1 (% predicted) range (mean) | Age range (mean) | Baseline ICS usage | FEV1 | amPEF | pmPEF | β agonist use | Withdrawals due to asthma |
---|---|---|---|---|---|---|---|---|---|---|---|---|
N = number of subjects; FP = fluticasone; ICS = inhaled corticosteroid; BDP = beclomethasone dipropionate. | ||||||||||||
Chervinsky6 | 331 | 8 | 50 | MDI | 60–90 (72) | ⩾18 (38) | 8–16 puffs BDP/day | ✓ | ✓ | ✓ | ✓ | ✓ |
200 | ||||||||||||
1000 | ||||||||||||
Wolfe7 | 281 | 12 | 200 | MDI | (65) | 12–87 (34) | 0 | × | ✓ | ✓ | ✓ | ✓ |
500 | ||||||||||||
1000 | ||||||||||||
Lawrence8 | 261 | 6 | 200 | Diskhaler | 50–80 (66) | 18–71 (38) | ⩾400 µg BDP/day | ✓ | ✓ | ✓ | ✓ | ✓ |
1000 | ||||||||||||
Wasserman4 | 321 | 12 | 100 | Diskhaler | 50–80 | 12–74 (29) | ⩾0 | ✓ | ✓ | ✓ | × | ✓ |
200 | ||||||||||||
500 | ||||||||||||
Pearlman9 | 342 | 12 | 100 | Diskhaler | 50–80 (67) | 12–72 (35) | ⩾0 | ✓ | ✓ | ✓ | ✓ | ✓ |
200 | ||||||||||||
500 | ||||||||||||
Ind2 | 496 | 24 | 500 | MDI | 16–75 (45) | 1000–1600 µg /day | × | ✓ | × | × | × | |
1000 | ||||||||||||
Raphael3 | 399 | 12 | 200 | MDI | 45–80 (65) | 12–72 (38) | 8–12 puffs BDP/day | ✓ | ✓ | ✓ | ✓ | ✓ |
500 |