Table 1

Cortisol and ACTH response to corticotropin releasing hormone (CRH) stimulation before and after 3 months of treatment

	Before		After		After – before
Variable	Mean	SD	Mean	SD	Mean	95% CI	p value*
UFC=urinary free cortisol.
Values are mean (SD).
*Paired t test.
Cortisol (ng/ml)
Basal	155	65	137	78	–18	–41 to 5	0.118
Peak	269	57	238	58	–31	–55 to –7	0.013
Delta	114	59	101	53	–13	–38 to 12	0.308
AUC	1275	303	1100	327	–175	–288 to –63	0.003

ACTH (pg/ml)
Basal	41	43	27	22	–14	–27 to –0.4	0.045
Peak	88	51	62	35	–26	–43 to –9	0.004
Delta	47	44	35	32	–12	–31 to 7	0.199
AUC	298	159	221	93	–77	–124 to –29	0.003

UFC	14.9	7.1	15.0	11.6	0.1	–5.2 to 5.4	0.967