Mean (SD) changes in systolic blood pressure, diastolic blood pressure, heart rate, QTc, and serum potassium levels 12 hours after inhalation of placebo, 100 μg Ro 25-1553 (Ro 100), 600 μg Ro 25-1553 (Ro 600), or 4.5 μg formoterol (Fo 4.5); n=22–23
| Placebo | Ro 100 | Ro 600 | Fo 4.5 | |
|---|---|---|---|---|
| Values sampled as followed: blood pressure sitting (repeatedly during 24 hours, see Methods), heart rate and QTc (from ECG conducted at 1, 12 and 24 hours), serum potassium (at 12 hours). | ||||
| Systolic blood pressure (mm Hg) | 16.2 (11.0) | 15.9 (9.4) | 14.4 (8.8) | 18.7 (12.1) |
| Diastolic blood pressure (mm Hg) | −7.5 (4.6) | −7.3 (6.2) | −11.6 (4.9) | −7.1 (5.2) |
| Heart rate (beats/min) | −0.4 (6.5) | 0.2 (6.6) | 2.9 (7.2) | 0.9 (6.0) |
| QTc (ms) | 2.7 (18.1) | 5.2 (21.2) | 5.3 (14.7) | 5.8 (21.7) |
| Serum potassium (mmol/l) | 0.00 (0.33) | 0.03 (0.30) | −0.07 (0.34) | −0.01 (0.34) |