AUC of doubling doses (DD) summed over 6–72 hours (short term effect) and over 2–6 weeks (long term effect) after start of treatment
| Treatment effect | Fluticasone (n=13) | Placebo (n = 13) | Difference (FP v placebo) | p value* |
|---|---|---|---|---|
| Post-treatment changes (48 hours, 1 week and 2 weeks) are compared with those at baseline and at 6 weeks (last dose). Standardised AUC values (AUC related to time period) and their comparisons between the groups are given as means (95% confidence intervals). | ||||
| *t test for independent groups. | ||||
| Short term effect: standardised AUC (6–72 h) | 1.60 (1.03 to 2.16) | 0.80 (0.19 to 1.41) | 0.79 (0.01 to 1.58) | 0.048 |
| Long term effect: standardised AUC (2–6 weeks) | 1.92 (1.08 to 2.76) | 0.46 (−0.22 to 1.14) | 1.46 (0.44 to 2.48) | 0.007 |
| Post-treatment v baseline: standardised AUC (48 h–2 weeks) | 1.13 (0.00 to 2.26) | 0.27 (−0.41 to 0.95) | 0.86 (−0.35 to 2.07) | 0.155 |
| Post-treatment v 6 weeks: standardised AUC (48 h–2 weeks) | −0.66 (−1.26 to −0.07) | 0.06 (−0.33 to 0.45) | −0.72 (−1.38 to −0.07) | 0.033 |