Table 2

Changes in perception, lung function, and airway responsiveness to mannitol in 33 subjects at baseline and 8 weeks after the reduction of their daily steroid dose by half. These subjects remained clinically well during the 8 weeks following the reduction in steroid dose. Sputum inflammatory cells were measured in14 subjects with sputum collected at both visits

Baseline8 weeks after reductionp value
Values are means or *geometric means and 95% confidence intervals of the mean.
ICS = inhaled corticosteroids; FEV1 = forced expiratory volume in 1 second; DRR = dose response ratio; PS20FEV1 = Borg score at 20% fall in FEV1.
Slope (Borg/FEV1 % fall)*0.20 (0.15 to 0.26)0.14 (0.10 to 0.20)0.013
Intercept (Borg units)1.05 (0.67 to 1.43)0.69 (0.42 to 0.96)0.010
PS20FEV1 (Borg units)6.16 (4.7 to 7.6)4.77 (3.7 to 5.9)0.003
Correlation coefficient0.84 (0.77 to 0.90)0.86 (0.80 to 0.92)0.76
FEV1 (% predicted)85.6 (78.5 to 92.6)84.7 (77.7 to 91.7)0.33
Resting Borg score0.48 (0.28 to 0.67)0.40 (0.23 to 0.56)0.33
Asthma score3.00 (2.47 to 3.53)3.29 (2.65 to 3.93)0.11
FEV1 max fall (%)14.6 (12.5 to 16.5)16.3 (14.4 to 18.3)0.06
*DRR mannitol (% fall FEV1/mg)0.036 (0.024 to 0.055)0.060 (0.039 to 0.094)0.004
ICS dose (μg/day, BDP equivalent)1019 (813 to 1225)506 (403 to 609)<0.0001
Exhaled NO (ppb)*18.7 (15.5 to 22.5)21.5 (15.7 to 28.2)0.50
Sputum inflammatory cells (% total inflammatory cells):
    N1414
    Eosinophils (%)*2.20 (1.02 to 4.78)19.6 (13.4 to 28.0)0.002
    Neutrophils (%)*16.6 (10.0 to 27.5)9.8 (5.8 to 16.4)0.17
    Macrophages (%)58.3 (44.8 to 76.0)58.9 (49.1 to 70.7)0.93
    Lymphocytes (%)2.5 (−0.33 to 5.4)1.48 (0.43 to 2.52)0.39