Pulmonary function on spirometric testing and bronchial responsiveness as assessed by methacholine challenge in the two groups at age 8
| Control (n=61) | Prophylactic (n=54) | Mean difference (95% CI) | p value (t test) | |
|---|---|---|---|---|
| FEV1=forced expiratory volume in 1 second; FEF25–75= mid forced expiratory flow. | ||||
| *Dose response: maximum change in FEV1 divided by cumulative dose of methacholine given for each subject. | ||||
| Values are given as geometric means with mean difference and 95% confidence intervals of the difference in means. | ||||
| FEV1 (% predicted) | 92.6 | 95.0 | 2.39 (minus;1.43 to 6.21) | 0.22 |
| Peak flow (% predicted) | 76.2 | 81.3 | 5.13 (−0.78 to 11.05) | 0.08 |
| FEF25–75 (% predicted) | 75.1 | 82.5 | 7.45 (−1.64 to 16.53) | 0.11 |
| Bronchial responsiveness* | 12.3 | 2.7 | 4.54 (1.20 to 17.12) | 0.03 |