Table 1

Characteristics of study subjects

Healthy subjects (n=15)Steroid naïve COPD patients (n=20)Steroid treated COPD patients (n=25)†
Groups were frequency matched by age and smoking habit. Data are expressed as means (SE).
COPD=chronic obstructive pulmonary disease; FEV1=forced expiratory volume in 1 second; FVC=forced vital capacity.
*p<0.01 compared with healthy subjects.
†Inhaled corticosteroids: beclomethasone dipropionate (dose range 0.2–1 mg/day), budesonide (dose range 0.4–0.8 mg/day), and fluticasone propionate (dose range 0.75–2 mg/day).
Age (years)60 (5)65 (2)67 (2)
F/M8/711/913/12
SmokingExExEx
Pack years>10>10>10
FEV1 (l)4.55 (0.29)1.29 (0.27)*1.41 (0.19)*
FVC (l)4.72 (0.31)2.41 (0.25)*2.56 (0.15)*
FEV1 (% pred)95.1 (4.5)52.4 (3.8)*50.6 (4.3)*
FVC (% pred)99.2 (3.7)79.4 (3.3)*74.9 (4.0)*
FEV1/FVC (%)96.4 (2.3)53.2 (2.8)*55.1 (3.3)*
AtopyNoNoNo
Treatment
    TheophyllineNo4/205/25
    β2 agonistsNo14/2015/25