Healthy subjects (n=15) | Steroid naïve COPD patients (n=20) | Steroid treated COPD patients (n=25)† | |
---|---|---|---|
Groups were frequency matched by age and smoking habit. Data are expressed as means (SE). | |||
COPD=chronic obstructive pulmonary disease; FEV1=forced expiratory volume in 1 second; FVC=forced vital capacity. | |||
*p<0.01 compared with healthy subjects. | |||
†Inhaled corticosteroids: beclomethasone dipropionate (dose range 0.2–1 mg/day), budesonide (dose range 0.4–0.8 mg/day), and fluticasone propionate (dose range 0.75–2 mg/day). | |||
Age (years) | 60 (5) | 65 (2) | 67 (2) |
F/M | 8/7 | 11/9 | 13/12 |
Smoking | Ex | Ex | Ex |
Pack years | >10 | >10 | >10 |
FEV1 (l) | 4.55 (0.29) | 1.29 (0.27)* | 1.41 (0.19)* |
FVC (l) | 4.72 (0.31) | 2.41 (0.25)* | 2.56 (0.15)* |
FEV1 (% pred) | 95.1 (4.5) | 52.4 (3.8)* | 50.6 (4.3)* |
FVC (% pred) | 99.2 (3.7) | 79.4 (3.3)* | 74.9 (4.0)* |
FEV1/FVC (%) | 96.4 (2.3) | 53.2 (2.8)* | 55.1 (3.3)* |
Atopy | No | No | No |
Treatment | |||
Theophylline | No | 4/20 | 5/25 |
β2 agonists | No | 14/20 | 15/25 |