Log transformed serum leptin values stratified according to severity of lung impairment
| Severity of FEV1 impairment | ||||||
|---|---|---|---|---|---|---|
| Quintile 1 (n=561) | Quintile 2 (n=562) | Quintile 3 (n=561) | Quintile 4 (n=562) | Quintile 5 (n=562) | p for trend | |
| Partial regression coefficients were derived from linear regression models. Each cell represents the mean (SE) expected increase in serum leptin values (on a logarithmic scale, fg/l) for each quintile group relative to the reference category (quintile 5). | ||||||
| †Adjusted for age, sex, smoking status, race, body mass index, and lung function (see methods). | ||||||
| BMI=body mass index. | ||||||
| Log transformed leptin values (fg/l) | 1.69 (0.78) | 1.67 (0.81) | 1.68 (0.78) | 1.65 (0.80) | 1.60 (0.79) | 0.059 |
| Unadjusted partial regression coefficient | 0.093 (0.047) | 0.069 (0.047) | 0.085 (0.047) | 0.0565 (0.047) | 0.0 (reference) | 0.059 |
| Partial regression coefficient adjusted for sex | 0.182 (0.034) | 0.119 (0.034) | 0.099 (0.034) | 0.050 (0.034) | 0.0 (reference) | 0.001 |
| Partial regression coefficient adjusted for sex and BMI | 0.250 (0.029) | 0.174 (0.029) | 0.141 (0.029) | 0.056 (0.029) | 0.0 (reference) | 0.001 |
| Fully adjusted partial regression coefficient†| 0.236 (0.029) | 0.190 (0.029) | 0.160 (0.029) | 0.077 (0.029) | 0.0 (reference) | 0.001 |