Epithelium | Lamina propria | |||||||
---|---|---|---|---|---|---|---|---|
Fluticasone propionate | Placebo | Fluticasone propionate | Placebo | |||||
Marker | Baseline | Post-intervention | Baseline | Post-intervention | Baseline | Post-intervention | Baseline | Post-intervention |
Data are expressed as median (range) ratios of immunostained areas and field measurement which consisted of the total area of either the epithelium or the lamina propria. Statistical analysis by paired Wilcoxon test after log transformation. | ||||||||
CD3 | 0.57 (0.10–4.52) | 0.28 (0.10–1.54) | 0.79 (0.35–2.23) | 0.45 (0.15–3.25) | 0.23 (0.04–5.71) | 0.20 (0.03–1.58) | 0.50 (0.20–1.40) | 0.31 (0.02–1.97) |
CD4 | 1.03 (0.14–4.00) | 0.70 (0.40–2.03) | 1.11 (0.19–1.79) | 1.19 (0.70–2.17) | 0.68 (0.07–5.61) | 0.54 (0.18–1.02) | 0.80 (0.14–9.0) | 0.58 (0.47–1.48) |
CD8 | 0.09 (0.05–0.60) | 0.09 (0.01–0.12) | 0.07 (0.03–0.26) | 0.07 (0.03–0.23) | 0.06 (0.03–0.42) | 0.03 (0.01–0.07) | 0.035 (0.03–0.16) | 0.02 (0.01–0.10) |
CD25 | 0.16 (0.07–3.28) | 0.20 (0.03–0.31) | 0.27 (0.03–1.28) | 0.15 (0.00–1.79) | 0.17 (0.05–2.39) | 0.15 (0.02–0.51) | 0.13 (0.03–0.47) | 0.06 (0.00–0.46) |
MBP | 0.06 (0.01–1.22) | 0.03 (0.01–0.25) | 0.20 (0.03–5.27) | 0.15 (0.00–1.05) | 0.29 (0.05–2.30) | 0.08 (0.01–0.64) | 0.46 (0.03–4.46) | 1.87 (0.00–6.45) |
EG2 | 0.16 (0.01–0.45) | 0.06 (0.02–0.31) | 0.08 (0.03–1.79) | 0.07 (0.01–0.47) | 0.22 (0.13–0.68) | 0.28 (0.01–1.01) | 0.28 (0.03–2.5) | 0.72 (0.01–4.69) |
CD15 | 3.31 (1.52–17.4) | 2.12 (0.08–8.68) | 4.32 (0.15–14.6) | 1.64 (0.53–27.70) | 0.40 (0.19–4.73) | 0.90 (0.19–3.73) | 0.68 (0.14–3.95) | 0.73 (0.15–3.98) |
CD68 | 1.42 (0.24–11.4) | 0.81 (0.23–2.64) | 1.64 (0.39–9.86) | 1.19 (0.37–5.12) | 1.77 (0.44–20.1) | 0.98 (0.26–2.77) | 2.67 (0.52–4.35) | 1.76 (0.58–5.64) |
CD1a | 0.14 (0.04–0.45) | 0.13 (0.05–0.29) | 0.10 (0.05–0.30) | 0.10 (0.01–0.19) | 0.16 (0.04–0.35) | 0.14 (0.04–0.59) | 0.12 (0.05–0.31) | 0.11 (0.02–0.21) |
Tryptase | 0.10 (0.03–0.63) | 0.02 (0.00–0.18) | 0.18 (0.03–0.61) | 0.10 (0.02–0.59) | 0.67 (0.19–3.26) | 0.44 (0.02–0.74) | 1.95 (0.12–4.03) | 0.91 (0.01–3.97) |