Phenotypic characteristics of study cohorts
| Pedigrees (n=1508) | Parents (n=681) | Non-asthma parents (n=492) | Asthma parents (n=189) | Sibling 1 (n=341) | Sibling 2 (n=338) | Controls (n=184) | |
|---|---|---|---|---|---|---|---|
| FEV1=forced expiratory volume in 1 second; BHR=bronchial hyperresponsiveness. | |||||||
| Age (years) | 24.6 | 40.5 | 40.7 | 40.2 | 13.0 | 9.9 | 42.3 |
| Sex (% male) | 51.8 | 49.9 | 51.0 | 47.1 | 56.9 | 53.6 | 47.0 |
| Asthma (%, doctor) | 60.1 | 27.8 | 0 | 100 | 100 | 100 | 0 |
| Eczema (%, questionnaire) | 45.6 | 32.7 | 25.8 | 50.8 | 57.8 | 62.4 | 0 |
| Hayfever (%, questionnaire) | 48.9 | 46.8 | 38.0 | 69.8 | 64.2 | 47.0 | 8.7 |
| Symptom score | 15.21 | 8.21 | 4.01 | 19.13 | 23.47 | 23.44 | ND |
| Drug score B | 1.90 | 0.65 | 0.08 | 2.20 | 3.40 | 3.45 | ND |
| FEV1 (% predicted) | 98.05 | 100.81 | 103.39 | 94.12 | 94.74 | 95.62 | ND |
| BHR (1/L slope+30)*1000 | 19.03 | 24.33 | 26.79 | 17.22 | 14.55 | 12.00 | ND |
| log IgE (age corrected) | 1.25 | 0.64 | 0.49 | 1.01 | 1.84 | 1.93 | ND |