Table 3

Effects of steroid treatment on pulmonary function, exhaled NO levels, and iNOS and nitrotyrosine (NT) immunopositive cell counts

FEV1 (l)PD20 (μmol)NO (ppb)iNOS positive cell count (×104/ml)NT positive cell count (×104/ml)
No.PrePostPrePostPrePostPrePostPrePost
FEV1=forced expiratory volume in 1 second; PD20=dose of histamine provoking a fall in FEV1 of 20% or more; pre and post=values before and after steroid (or placebo) treatment.
*p<0.05, **p<0.01 compared with values before steroid treatment.
Steroid treatment group
11.431.690.0270.055163343.19.355.227.2
20.680.690.0200.02110875.071.3160.0141.0
30.790.970.0680.224131041.321.345.124.6
41.461.530.2550.22810892.070.072.971.1
50.850.930.0820.140151068.436.5103.066.0
60.690.790.0390.106141787.855.395.046.1
71.051.180.1750.553181077.024.2146.040.7
81.021.240.1390.2308834.413.228.324.4
91.221.010.1640.1579103.13.415.118.2
101.331.400.0100.0287853.339.275.927.3
111.451.500.1500.230303121.818.422.721.4
121.071.260.0400.15014255.926.4102.049.5
Mean1.091.18*0.0970.177*13.712.954.432.4**76.846.5**
SE0.090.090.020.041.92.98.26.914.110.4
Placebo treatment group
130.660.680.0250.020262995.874.0160.082.3
141.972.040.1240.1375794.870.179.054.7
151.751.810.1780.236111248.354.447.257.8
161.701.710.1980.185171617.322.023.337.0
171.091.020.0760.068111139.151.145.967.0
181.351.350.1120.1255567.635.364.845.5
Mean1.421.440.1190.12912.513.360.551.270.057.4
SE0.220.230.030.033.63.814.18.921.47.1