Causal drugs and chest HRCT patterns of pneumonitis
| Drug | n | DAD | CIP | BOOP/EP | HP |
|---|---|---|---|---|---|
| DAD=diffuse alveolar damage; CIP=chronic interstitial pneumonia; BOOP=bronchiolitis obliterans organising pneumonia; HP=hypersensitivity pneumonitis; EP=eosinophilic pneumonia; NSAIDs=non-steroidal anti-inflammatory drugs. | |||||
| *Cytotoxic agents included peplomycin (n=3), bleomycin (n=1), tegafur/uracil (n=2), and methotrexate (n=1). | |||||
| †NSAIDs included loxoprofen (n=2), diclofenac (n=2), acetaminophen (n=2), and mesalazine (n=1). | |||||
| ‡Antibiotics included panipenem/betamiprom (n=2), minocycline (n=3), clarithromycin (n=1), cefepime (n=1), and cefozopran (n=1). | |||||
| §Other agents included gold salt (n=2), carvedilol (n=1), bisoprolol (n=1), maprotiline (n=1), naftopidil (n=1), decamethylcyclopentasiloxane (n=1), and herbal Gosha-jinki-gan (n=1). | |||||
| Cytotoxic agents* | 7 | 3 | 3 | 1 | – |
| NSAIDs† | 7 | 1 | 1 | 3 | 2 |
| Antibiotics‡ | 8 | 1 | 4 | 2 | 1 |
| Others§ | 8 | 2 | 3 | 2 | 1 |
| Total | 30 | 7 | 11 | 8 | 4 |