Baseline surfactant protein level and outcomes among patients with ALI/ARDS
| Measurement | Risk of death OR (95% CI) | Mean change in ventilator-free days (95% CI) | p value | Mean change in organ failure-free days (95% CI) | p value |
|---|---|---|---|---|---|
| *Logistic or linear regression analysis controlling for ventilation strategy (6 ml/kg v 12 ml/kg). | |||||
| †Controlling for ventilation strategy, APACHE III score, Pao2/Fio2 ratio, creatinine, platelet count. | |||||
| Spearman correlation between SP-D level and creatinine (r =−0.15, p=0.0006), Pao2/Fio2 ratio (r =−0.12, p=0.0044), platelets (r =0.15, p=0.0003), and APACHE III score (r =0.03, p=0.53) | |||||
| SP-A=surfactant protein A; SP-D=surfactant protein D. | |||||
| SP-A level per 100 ng/ml increment* | 0.88 (0.65 to 1.17) | 0.77 (−0.66 to 2.19) | 0.29 | 0.85 (−0.63 to 2.33) | 0.26 |
| SP-A level per 100 ng/ml increment (multivariate)† | 0.92 (0.68 to 1.27) | 0.54 (−0.84 to 1.92) | 0.44 | 0.34 (−1.03 to 1.70) | 0.63 |
| SP-D level per 100 ng/ml increment* | 1.16 (1.05 to 1.29) | −0.97 (−1.49 to −0.44) | 0.0003 | −0.94 (−1.48 to −0.40) | 0.0007 |
| SP-D level per 100 ng/ml increment (multivariate)† | 1.21 (1.08 to 1.35) | −0.88 (−1.41 to −0.36) | 0.001 | −1.06 (−1.57 to −0.55) | <0.0001 |