Characteristics of patients
| Case 1 | Case 2 | Case 3 | |
|---|---|---|---|
| LDH=lactate dehydrogenase; A–a gradient=alveolar–arterial gradient. | |||
| Age (years) | 17 | 42 | 56 |
| Diagnosis | Hodgkin's disease | Chronic lymphocytic leukaemia | Glioblastoma multiforme |
| Corticosteroids | Yes | Yes | Yes |
| Chemotherapy | Yes | Yes | No |
| Symptoms | |||
| Fever | No | Yes | No |
| Cough | Mild | Mild | Mild |
| Dyspnoea | No | No | Mild |
| Radiographs | Reticulonodular infiltrates | Reticulonodular infiltrates | Reticulonodular infiltrates |
| Serum LDH (<200) (U/l) | 194 | 217 | 200 |
| Transfer factor (% predicted) | 29 | 73 | 46 |
| A–a gradient (mm Hg) | |||
| Rest | 23 | 53 | 45 |
| Exercise | 40 | 54 | 50 |
| Bronchoscopy | |||
| BAL | Negative | Negative | Negative |
| Transbronchial biopsy | Interstitial fibrosis | – | Interstitial fibrosis |