Decline in FEV1 (ml/year) in non-smoking asthmatics and controls in different putative IL-1 haplotypes
| IL-1 haplotype | (1) IL1RN A2/ IL1B –511T | (2) IL1RN A2/ IL1B –511C | (3) IL1RN A1/ IL1B –511T | (4) IL1RN A1/ IL1B –511C | p value* | Post hoc tests between allele groups† |
|---|---|---|---|---|---|---|
| *Two way analysis of variance; †LSD test of means. | ||||||
| Non-smoking controls (n=124) | 41.8 (13.8) (n=54) | 44.8 (12.3) (n=32) | 50.7 (11.2) (n=7) | 45.5 (19.4) (n=31) | 0.27 | Not tested |
| Non-smoking new asthma cases (n=40) | 63.2 (24.6) (n=18) | 37.7 (20.7) (n=4) | 30.9 (16.9) (n=4) | 51.0 (24.8) (n=14) | 0.0443 | 3<1, p=0.02 2<1, p=0.06 |