Assessment of asthma severity and change in cognitive function at study entry (baseline) and 5 year follow up (end point) in asthma patients with Alzheimer's disease
| MMSE score | Asthma symptom score | Daily inhaler puffs | Number of hospital admissions for asthma | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Case | Age (y) | Sex | Baseline | End point | Baseline | End point | Baseline | End point | Baseline | End point |
| MMSE=Mini-Mental State Examination; SE=standard error. | ||||||||||
| *p<0.0001 (Wilcoxon rank test) compared with baseline data in all asthma patients with Alzheimer's disease; †p<0.0001; ‡p=0.0001; §p<0.0001 compared with baseline data in seven asthma patients with Alzheimer's disease (cases 1–7). | ||||||||||
| 1 | 67 | M | 23 | 18 | 6.4 | 1.2 | 1.3 | 0 | 2 | 0 |
| 2 | 66 | M | 21 | 16 | 8.6 | 2.2 | 1.4 | 0 | 2 | 0 |
| 3 | 70 | F | 23 | 17 | 10.2 | 1.6 | 2.4 | 0 | 3 | 1 |
| 4 | 65 | M | 22 | 15 | 7.8 | 1.2 | 2.6 | 1.4 | 3 | 0 |
| 5 | 65 | F | 21 | 16 | 7.5 | 0.4 | 3.3 | 1 | 2 | 0 |
| 6 | 69 | F | 23 | 17 | 9.4 | 3.6 | 1.9 | 0.4 | 3 | 0 |
| 7 | 66 | F | 22 | 16 | 9.2 | 2.4 | 2.2 | 0 | 2 | 0 |
| 8 | 68 | M | 23 | 21 | 7.6 | 7.4 | 2.8 | 2.6 | 3 | 2 |
| Mean (SE) | 67.0 (0.7) | 22.3 (0.3) | 17.0 (0.7)* | 8.4 (0.5) | 1.8 (0.4)† | 2.2 (0.3) | 0.4 (0.2)‡ | 2.4 (0.2) | 0.1 (0.1)§ | |