Predictors of cardiovascular medication use in OSAS
| Risk factor | Anti-adrenergic drugs | Diuretics | Loop diuretics | Beta blockers | Calcium channel blockers | ACE-I | OCD | Cholesterol and triglyceride reducers |
|---|---|---|---|---|---|---|---|---|
| Values are odds ratio (95% confidence interval) with unit increase in variable. | ||||||||
| ACE-I=ACE inhibitor; OCD=other cardiac drugs (see box 1); BMI=body mass index; AHI=apnoea/hypopnoea index; time<90%=percentage time below an Sao2 of 90%; ESS=Epworth sleepiness scale score; – = variable eliminated from model. | ||||||||
| Illustrative examples to aid interpretation: In OSAS patients, use of diuretics is more likely (317%) and that of OCD less likely (60%) in females than in males. One unit increase in AHI is associated with a 2% increase in the likelihood of using anti-adrenergic drugs or diuretics. In addition to age and BMI, AHI increases the probability of using ACE-I in OSAS patients. An increase in ESS is not associated with an increase in the use of cardiovascular medications. On the other hand, time <90% is associated with increased odds of using diuretics; and AHI with increased odds of using anti-adrenergic drugs, diuretics, and ACE-I. | ||||||||
| Sex (female/male) | – | 3.17 | – | – | – | – | 0.40 | – |
| (1.74 to 5.75) | (0.16 to 1.00) | |||||||
| Age (per + 1 year) | 1.09 | 1.07 | 1.09 | 1.06 | 1.07 | 1.07 | 1.09 | 1.07 |
| (1.03 to 1.15) | (1.04 to 1.09) | (1.05 to 1.13) | (1.03 to 1.09) | (1.04 to 1.09) | (1.05 to 1.10) | (1.06 to 1.13) | (1.04 to 1.11) | |
| BMI (per + 1 unit) | – | – | 1.07 | – | 1.04 | 1.05 | 1.06 | – |
| (1.02 to 1.12) | (1.01 to 1.07) | (1.02 to 1.08) | (1.01 to 1.11) | |||||
| AHI (per + 1 unit) | 1.02 | 1.02 | – | – | – | 1.01 | – | – |
| (1.00 to 1.04) | (1.01 to 1.03) | (1.00 to 1.02) | ||||||
| Time <90% (per +1%) | – | – | 1.02 | – | – | – | – | – |
| (1.01 to 1.04) | ||||||||
| ESS (per +1 point) | – | – | – | – | – | – | – | – |