Table 1

Randomised prospective studies of ventilatory strategies to limit lung overdistension in patients with ARDS

Referencen“Protective”ControlMortality
Vt=tidal volume; PIP=peak inspiratory pressure; Pplat=end inspiratory plateau pressure; PEEP=positive end expiratory pressure.
Stewart (1998)16120• Vt <8 ml/kg• Vt 10–15 ml/kgNo difference
• PIP <30 cm H2O• PIP <50 cm H2O
• PEEP levels similar in both groups
Brochard (1998)17116• Vt <10 ml/kg• Vt 10 ml/kgNo difference
• Pplat <25 cm H2O• Normocapnia
• PEEP levels similar in both groups
Brower (1999)18 52• Vt 5–8 ml/kg• Vt 10–12 ml/kgNo difference
• Pplat <30 cm H2O• Pplat <45–55 cm H2O
ARDSNet (2000)1861• Vt 6 ml/kg• Vt 12 ml/kgLower in “protective” group (31% v 40%)
• PIP <30 cm H2O• PIP <50 cm H2O