Bone biochemistry in 96 adults with cystic fibrosis
| Baseline | Difference between baseline and follow up | |
|---|---|---|
| Values are mean (95% CI) or median (25–75% IQR). *p<0.05; †p<0.01; ‡p<0.001. | ||
| Corrected calcium (mmol/l) (normal range 2.10–2.65) | 2.36 (95% CI 2.34 to 2.38) | −0.06 (95% CI −0.09 to −0.04)‡ |
| Phosphate (mmol/l) (normal range 0.7–1.4) | 1.10 (95% CI 1.05 to 1.14) | 0.03 (95% CI −0.02 to 0.08) |
| Total alkaline phosphatase (IU/l) (normal range 25.0–110.0) | 93.0 (25–75% IQR 67.0–125.0) | 7.0 (25–75% IQR −3.0–19.0)‡ |
| 25-hydroxyvitamin D (ng/ml) (normal range 5.0–30.0) | 18.9 (95% CI 16.5 to 21.2) | 2.40 (95% CI 0.04 to 4.78)* |
| 1,25-dihydroxyvitamin D (pg/ml) | 31.4 (95% CI 28.9 to 33.9) (normal range 20.0–50.0) | 4.62 (95% CI 1.54 to 7.71)† |
| Parathyroid hormone (pg/ml) (normal range 10.0–60.0) | 23.0 (25–75% IQR 16.0–31.0) | 2.7 (25–75% IQR −6.4–10.1) |
| Bone specific alkaline phosphatase (U/l) (normal range 10.0–23.0) | 18.5 (25–75% IQR 14.3–24.3) | 1.1 (25–75% IQR −1.4–4.2)† |
| Deoxypyridinoline crosslinks (nM/Mm) (normal range 2.3–7.4) | 5.8 (25–75% IQR 4.7–9.3) | 0.0 (25–75% IQR −2.1–1.8) |