Table 2

Airway inflammation in patients with COPD with (PiZ) and without (PiM) α1–AT deficiency

PiZ (n=11)PiM (n=11)Mean difference (95% CI)p value
LTB4=leukotriene B4; IL-8=interleukin8; MPO=myeloperoxidase.
Data are presented as mean (SE).
LTB4 (nM)17.54 (4.14)11.29 (6.89)6.25 (–10.53 to 23.04)0.023
IL-8 (nM)8.75 (2.16)3.50 (0.61)5.25 (0.56 to 9.94)0.015
Elastase (μM)0.02 (0.00)0.00 (0.00)0.02 (0.01 to 0.03)0.010
MPO (mg/l)8.58 (2.49)6.30 (0.82)0.19 (–0.27 to0.65)0.326