Mean (SE) changes in respiratory parameters after saline on two days and after salbutamol and ipratropium alone and in combination on each of the two days tested
| FEV1(l) | FVC (l) | IC (l) | SVC (l) | FEV1/FVC (%) | FEV1/SVC (%) | |
| Saline (day 1) | 0.02 (0.01) | 0.02 (0.01) | 0.00 (0.04) | –0.01 (0.07) | 0.83 (1.15) | 0.69 (0.52) |
| Saline (day 2) | 0.01 (0.02) | 0.01 (0.02) | 0.07 (0.04) | 0.16 (0.06) | 0.36 (0.96) | 0.92 (0.62) |
| Salbutamol | 0.11 (0.02)2-150 | 0.33 (0.05)2-150 | 0.21 (0.05)2-150 | 0.35 (0.06)2-150 | –0.66 (0.91) | 0.82 (1.0) |
| Ipratropium | 0.09 (0.02)2-150 | 0.34 (0.05)2-150 | 0.22 (0.04)2-150 | 0.35 (0.06)2-150 | –0.69 (0.63) | –0.79 (1.0) |
| Combination (day 1) | 0.16 (0.02)2-150 | 0.44 (0.07)2-150 | 0.34 (0.06)2-150 | 0.42 (0.08)2-150 | –2.06 (2.13) | 2.15 (1.3) |
| Combination (day 2) | 0.15 (0.02)2-150 | 0.46 (0.07)2-150 | 0.34 (0.06)2-150 | 0.45 (0.08)2-150 | –2.32 (1.97) | 0.42 (1.08) |
FEV1 = forced expiratory volume in one second; FVC = forced vital capacity; IC = inspiratory capacity; SVC = slow vital capacity.
Day 1 represents the day on which all subjects received salbutamol first, and day 2 is the day on which the first active drug given was ipratropium.
↵2-150 p<0.001 compared with baseline.