Table 2

Mean (SE) changes in respiratory parameters after saline on two days and after salbutamol and ipratropium alone and in combination on each of the two days tested

FEV1(l) FVC (l) IC (l) SVC (l) FEV1/FVC (%) FEV1/SVC (%)
Saline (day 1)0.02 (0.01)0.02 (0.01)0.00 (0.04)–0.01  (0.07)0.83  (1.15)0.69  (0.52)
Saline (day 2)0.01 (0.02)0.01 (0.02)0.07 (0.04)0.16 (0.06)0.36 (0.96)0.92 (0.62)
Salbutamol0.11 (0.02)2-150 0.33 (0.05)2-150 0.21 (0.05)2-150 0.35 (0.06)2-150 –0.66 (0.91)0.82 (1.0)
Ipratropium0.09 (0.02)2-150 0.34 (0.05)2-150 0.22 (0.04)2-150 0.35 (0.06)2-150 –0.69 (0.63)–0.79 (1.0)
Combination (day 1)0.16 (0.02)2-150 0.44 (0.07)2-150 0.34 (0.06)2-150 0.42 (0.08)2-150 –2.06 (2.13)2.15 (1.3)
Combination (day 2)0.15 (0.02)2-150 0.46 (0.07)2-150 0.34 (0.06)2-150 0.45 (0.08)2-150 –2.32 (1.97)0.42 (1.08)
  • FEV1 = forced expiratory volume in one second; FVC = forced vital capacity; IC = inspiratory capacity; SVC = slow vital capacity.

  • Day 1 represents the day on which all subjects received salbutamol first, and day 2 is the day on which the first active drug given was ipratropium.

  • 2-150 p<0.001 compared with baseline.