Risk of atopy* in a cohort of 889 pregnant women according to history of infection before the age of 7 years
| Infection history | Cases/all (%) | OR (95% CI) | Adjusted OR† (95% CI) | p value |
|---|---|---|---|---|
| OR=odds ratio; CI=confidence interval. *Atopy defined as a specific IgE level of ≥0.35 kU/l. †Adjusted for birth cohort, social class in childhood, and sibship size. ‡Positive history of infection before the age of 7 years but age at infection not specified. §p values are tests for homogeneity. These test for a differential effect of infection at different ages within the age span 0–6 years. | ||||
| Measles | ||||
| No | 48/205 (23.4%) | 1 (reference) | 1 (reference) | |
| Yes | 207/672 (30.8%) | 1.46 (1.01 to 2.09) | 1.40 (0.97 to 2.03) | |
| Age (years) | ||||
| 0 | 15/28 (53.6%) | 3.77 (1.68 to 8.48) | 3.36 (1.47 to 7.68) | |
| 1 | 23/69 (33.3%) | 1.64 (0.90 to 2.97) | 1.56 (0.85 to 2.87) | |
| 2–3 | 52/219 (23.7%) | 1.02 (0.65 to 1.60) | 0.97 (0.61 to 1.53) | }0.01§ |
| 4–6 | 70/222 (31.5%) | 1.51 (0.98 to 2.31) | 1.45 (0.93 to 2.25) | |
| Unspecified‡ | 47/134 (35.1%) | 1.77 (1.09 to 2.86) | 1.74 (1.06 to 2.86) | |
| Missing | 6/12 (50.0%) | – | – | |
| Rubella | ||||
| No | 117/428 (27.3%) | 1 (reference) | 1 (reference) | |
| Yes | 129/426 (30.3%) | 1.15 (0.86 to 1.55) | 1.13 (0.83 to 1.53) | |
| Age (years) | ||||
| 0 | 19/46 (41.3%) | 1.87 (1.00 to 3.49) | 1.80 (0.95 to 3.42) | |
| 1 | 12/45 (26.7%) | 0.97 (0.48 to 1.93) | 0.82 (0.40 to 1.67) | |
| 2–3 | 28/99 (28.3%) | 1.05 (0.64 to 1.70) | 1.02 (0.61 to 1.68) | }0.33§ |
| 4–6 | 36/120 (30.0%) | 1.14 (0.73 to 1.78) | 1.13 (0.72 to 1.78) | |
| Unspecified‡ | 34/116 (29.3%) | 1.10 (0.70 to 1.73) | 1.12 (0.71 to 1.79) | |
| Missing | 15/35 (42.9%) | – | – | |
| Varicella | ||||
| No | 74/268 (27.6%) | 1 (reference) | 1 (reference) | |
| Yes | 181/606 (29.9%) | 1.12 (0.81 to 1.54) | 1.13 (0.81 to 1.58) | |
| Age (years) | ||||
| 0 | 9/34 (26.5%) | 0.94 (0.42 to 2.12) | 0.95 (0.41 to 2.17) | |
| 1 | 25/74 (33.8%) | 1.34 (0.77 to 2.32) | 1.32 (0.75 to 2.33) | |
| 2–3 | 39/152 (25.7%) | 0.90 (0.58 to 1.42) | 0.93 (0.58 to 1.48) | }0.64§ |
| 4–6 | 63/209 (30.1%) | 1.13 (0.76 to 1.69) | 1.13 (0.75 to 1.71) | |
| Unspecified‡ | 45/137 (32.8%) | 1.28 (0.82 to 2.00) | 1.30 (0.82 to 2.06) | |
| Missing | 6/15 (40.0%) | – | – | |
| Mumps | ||||
| No | 174/610 (28.5%) | 1 (reference) | 1 (reference) | |
| Yes | 80/264 (30.3%) | 1.09 (0.79 to 1.49) | 1.08 (0.79 to 1.49) | |
| Age (years) | ||||
| 0 | 1/5 (20.0%) | 0.63 (0.07 to 5.64) | 0.78 (0.08 to 7.15) | |
| 1 | 2/13 (15.4%) | 0.46 (0.10 to 2.08) | 0.48 (0.10 to 2.22) | |
| 2–3 | 25/81 (30.9%) | 1.12 (0.68 to 1.85) | 1.07 (0.64 to 1.77) | }0.49§ |
| 4–6 | 32/100 (32.0%) | 1.18 (0.75 to 1.86) | 1.20 (0.76 to 1.91) | |
| Unspecified‡ | 20/65 (30.8%) | 1.11 (0.64 to 1.94) | 1.10 (0.62 to 1.93) | |
| Missing | 7/15 (46.7%) | – | – | |