Table 3

Adjusted† odds ratios (95% CI) for wheezing patterns associated with paracetamol and aspirin use (n=9400)

Transient infant wheeze* (n=1310)Later onset wheeze** (n=783)Persistent wheeze*** (n=475)
*Wheezing <6 months but not at 30–42 months.
**Wheezing at 30–42 months but not <6 months.
***Wheezing <6 months and at 30–42 months.
†Adjusted for factors in table 1 and compared with non-wheezers (no wheezing <6 months and at 30–42 months).
Paracetamol use in pregnancy:
0–20 weeks
    Never1.001.001.00
    Some days1.13 (0.99 to 1.29)1.18 (1.00 to 1.38)0.97 (0.78 to 1.19)
    Most days/daily1.45 (0.87 to 2.44)1.18 (0.56 to 2.49)1.41 (0.72 to 2.74)
    Unknown1.43 (0.78 to 2.63)1.41 (0.72 to 2.74)1.77 (0.80 to 3.91)
20–32 weeks
    Never1.001.001.00
    Some days1.07 (0.93 to 1.22)1.19 (1.01 to 1.40)1.05 (0.85 to 1.30)
    Most days/daily0.88 (0.44 to 1.73)1.72 (0.87 to 3.40)2.34 (1.24 to 4.40)
    Unknown1.31 (0.48 to 3.58)0.41 (0.21 to 0.82)1.04 (0.22 to 4.95)
Aspirin use in pregnancy:
0–20 weeks
    Never1.001.001.00
    Some days0.86 (0.61 to 1.20)1.13 (0.79 to 1.61)1.43 (0.93 to 2.21)
    Most days/daily2.73 (1.57 to 4.76)1.95 (0.90 to 4.20)0.83 (0.22 to 3.19)
    Unknown1.38 (0.70 to 2.71)1.61 (0.78 to 3.31)1.86 (0.76 to 4.53)
20–32 weeks
    Never1.001.001.00
    Some days0.86 (0.56 to 1.31)0.83 (0.50 to 1.38)1.33 (0.76 to 2.35)
    Most days/daily2.54 (1.51 to 4.29)1.02 (0.39 to 2.62)0.72 (0.19 to 2.70)
    Unknown1.29 (0.47 to 3.51)0.38 (0.19 to 0.76)1.00 (0.21 to 4.77)
Paracetamol use in infancy:
0–6 months
    Never1.001.001.00
    Once0.84 (0.66 to 1.06)0.94 (0.72 to 1.24)1.30 (0.84 to 2.00)
    More than once1.21 (0.99 to 1.48)1.22 (0.97 to 1.54)1.64 (1.13 to 2.39)