Day care attendance before age 5 and association with allergic disease in adulthood in subjects with and without siblings
| Subjects with no siblings | Subjects with siblings | |||||
|---|---|---|---|---|---|---|
| Day care | N symptoms/total* | OR (95% CI)† | N symptoms/total* | OR (95% CI)† | p value for interaction† | |
| *For each question some subjects answered “don’t know”, hence the totals are not 18 530. | ||||||
| †Estimated by logistic regression adjusted for number of siblings, bedroom sharing, serious respiratory infections, sex, age, parental smoking, current smoking, current occupation, and centre. | ||||||
| Wheeze | No | 164/812 | 1 | 1844/7996 | 1 | |
| Yes | 230/946 | 1.48 (1.12 to 1.95) | 1827/8012 | 0.97 (0.89 to 1.06) | 0.025 | |
| Wheeze + SOB | No | 78/809 | 1 | 899/7981 | 1 | |
| Yes | 113/945 | 1.33 (0.92 to 1.92) | 949/8001 | 1.02 (0.91 to 1.14) | NS | |
| Wheeze – cold | No | 100/808 | 1 | 1103/7976 | 1 | |
| Yes | 129/944 | 1.26 (0.90 to 1.76) | 1067/7997 | 0.94 (0.84 to 1.04) | NS | |
| Hay fever | No | 252/811 | 1 | 2069/7980 | 1 | |
| Yes | 253/944 | 0.76 (0.60 to 0.98) | 2122/7998 | 1.05 (0.97 to 1.14) | 0.043 | |
| Eczema | No | 335/811 | 1 | 3106/7991 | 1 | |
| Yes | 378/946 | 1.08 (0.86 to 1.36) | 2975/8002 | 1.04 (0.96 to 1.12) | NS | |