Mutually adjusted effects of childhood exposures on symptoms in subjects aged 20–44 years
| Variable | Wheeze* | Wheeze + SOB† | Wheeze – cold‡ | Waking with SOB§ | Hay fever¶ | Eczema** |
|---|---|---|---|---|---|---|
| Values are odds ratios (95% CI) estimated by logistic regression adjusted for age, sex, parental smoking, current smoking, current occupation, and study centre. | ||||||
| SOB = shortness of breath. | ||||||
| *“Have you had wheezing or whistling in your chest at any time in the last 12 months?” | ||||||
| †“(If yes) have you been at all breathless when the wheezing was present?” | ||||||
| ‡“(If yes) have you had this wheezing or whistling when you did not have a cold?” | ||||||
| §“Have you been woken by an attack of shortness of breath at any time in the last 12 months?” | ||||||
| ¶“Do you have any nasal allergies, including hay fever?” | ||||||
| **“Have you ever had eczema or any kind of skin allergy?” | ||||||
| Family size | ||||||
| 0 sibs | 1 | 1 | 1 | 1 | 1 | 1 |
| 1 sib | 0.95 (0.83 to 1.09) | 0.98 (0.82 to 1.18) | 1.00 (0.83 to 1.18) | 1.00 (0.79 to 1.28) | 0.94 (0.83 to 1.06) | 0.94 (0.84 to 1.06) |
| 2 sibs | 0.90 (0.78 to 1.04) | 0.92 (0.76 to 1.11) | 0.91 (0.76 to 1.08) | 0.97 (0.75 to 1.25) | 0.84 (0.74 to 0.96) | 0.93 (0.82 to 1.05) |
| 3 sibs | 0.96 (0.82 to 1.13) | 1.13 (0.92 to 1.38) | 1.04 (0.86 to 1.27) | 1.16 (0.88 to 1.52) | 0.78 (0.67 to 0.90) | 0.91 (0.79 to 1.04) |
| ≥4 sibs | 1.04 (0.89 to 1.21) | 1.17 (0.95 to 1.43) | 1.09 (0.90 to 1.32) | 1.22 (0.94 to 1.60) | 0.74 (0.64 to 0.85) | 0.85 (0.75 to 0.97) |
| Bedroom sharing | ||||||
| No | 1 | 1 | 1 | 1 | 1 | 1 |
| Yes | 1.05 (0.97 to 1.14) | 1.02 (0.92 to 1.13) | 1.03 (0.93 to 1.13) | 0.97 (0.85 to 1.12) | 0.97 (0.90 to 1.05) | 0.98 (0.91 to 1.05) |
| Day care attendance | ||||||
| No | 1 | 1 | 1 | 1 | 1 | 1 |
| Yes | 1.01 (0.93 to 1.10) | 1.04 (0.94 to 1.16) | 0.96 (0.87 to 1.07) | 1.02 (0.89 to 1.18) | 1.01 (0.94 to 1.10) | 1.04 (0.97 to 1.12) |
| Serious respiratory infection | ||||||
| No | 1 | 1 | 1 | 1 | 1 | 1 |
| Yes | 1.86 (1.66 to 2.09) | 2.06 (1.80 to 2.37) | 1.70 (1.49 to 1.95) | 1.85 (1.54 to 2.22) | 1.44 (1.29 to 1.61) | 1.34 (1.20 to 1.49) |