Eiser11 (a) | 4 withdrawals: 1 chest infection, 1 itching on diamorphine, 1 constipation on diamorphine, 1 headache due to cerebral metastases |
Eiser11 (b) | 2 drop outs: 1 developed chest pain between 2 test days, 1 suffered deterioration in blood gases (unclear whether had received medication or placebo when this occurred) |
Johnson12 | 1 drop out: developed chest infection and right heart failure on dihydrocodeine |
Woodcock16 | 5 drop outs: nausea and vomiting on dihydrocodeine |
Noseda24 | 3 drop outs: 3 patients died over the study period during the night (the authors did not consider their deaths to be related to the treatment) |