Table 2

Median (interquartile range) IC50 values of budesonide, formoterol, and the combination of the two drugs on inhibition of GM-CSF production and ICAM-1 and VCAM-1 upregulation by human lung fibroblasts after IL-1β stimulation

Activation parameterIC50 budesonideIC50 formoterolIC50 combination
ICAM-12.2 (0.7–2.9) × 10−82.6 (1.6–4.3) × 10−87.7 (7.0–18.2) × 10−10
VCAM-11.4 (1.1–6.8) × 10−91.0 (0.5–2.4) × 10−82.1 (1.0–3.0) × 10−10
GM-CSF0.9 (0.8–1.0) × 10−107.9 (7.1–9.0) × 10−100.8 (0.7–0.9) × 10−10
IL-81.5 (0.8–2.6) × 10−101.8 (1.0–4.4) × 10−10