Airway and systemic data
| Pooled baseline | FLU-HFA (500 μg/day) | FLU-HFA (1000 μg/day) | BEC-HFA (500 μg/day) | BEC-HFA (1000 μg/day) | |
|---|---|---|---|---|---|
| BEC-HFA=HFA-134a solution formulation of beclomethasone dipropionate; FLU-HFA=HFA-134a suspension formulation of fluticasone propionate; PD20=dose of methacholine provoking a fall in FEV1 of 20% or more; NO=nitric oxide; FEV1=forced expiratory volume in 1 second; PEF=peak expiratory flow; OUCC=overnight urinary cortisol/creatinine. | |||||
| Values are expressed as means (SE) except methacholine PD20, nitric oxide and urine data which are expressed as geometric means (SE). | |||||
| *Denotes significant (p<0.05) difference from pooled baseline: † denotes significant (p<0.05) difference between FLU-HFA and BEC-HFA at 1000 μg/day dose. | |||||
| Airway data | |||||
| Methacholine PD20 (μg) | 96.6 (22.1) | 308.3 (93.2)* | 416.0 (145.7)* | 234.1 (72.9)* | 245.9 (71.0)* |
| Exhaled tidal NO (ppb) | 9.7 (1.5) | 4.8 (0.8)* | 4.9 (0.7)* | 4.9 (0.6)* | 5.0 (1.1)* |
| FEV1 (% predicted) | 88.5 (2.5) | 92.8 (2.4)* | 91.9 (2.4)* | 92.8 (2.3)* | 93.0 (2.2)* |
| Morning PEF (l/min) | 443 (19) | 455 (20)* | 457 (20)* | 455 (21)* | 461 (20)* |
| Systemic data | |||||
| OUCC (nmol/mmol) | 6.59 (0.70) | 4.78 (0.62) | 5.62 (0.98) | 3.91 (0.58)* | 2.86 (0.60)*† |