Levels of MMP–8, MMP–9, TIMP–1 and the percentage of neutrophils in BAL fluid of patients with cystic fibrosis and healthy controls at two different time points of the investigation
| MMP–8 (ng/ml) | MMP–9 (ng/ml) | TIMP–1 (ng/ml) | Neutrophils (%) | |
|---|---|---|---|---|
| Data are expressed as median (range). t0=baseline BAL; t1=BAL after 18 months. | ||||
| *Significantly different from DNase treated CF patients (p<0.05). | ||||
| DNase treated (n=13) | ||||
| t0 | 42 (8–137) | 55 (21–238) | 43 (23–89) | 39 (15–82) |
| t1 | 30.5 (9–57) | 35.5 (12–95) | 36 (20–61) | 21 (9–96) |
| t1–t0 | –23 (–40 to +58) | –20 (–213 to 50) | –13 (–67 to +34) | –15 (–40 to +58) |
| Untreated (n=10) | ||||
| t0 | 22 (4–39) | 23 (5–78) | 37 (15–78) | 28 (3–71) |
| t1 | 34.5 (22–60) | 40 (21–137) | 42.5 (31–61) | 32.5 (12–80) |
| t1–t0 | 15 (–49 to +48)* | 16 (–50 to +106)* | 11.5 (–41 to +34) | 20 (–49 to +48) |
| Controls (n=11) | ||||
| Mean (SD) | 0.1 (0.1) | 0.5 (0.02) | 4.1 (1.7) | |
| Range | 0.1–0.2 | 0.4–0.6 | 0.1–16 | |