Relationship of 30 year cumulative incidence of fracture, cataract, ever and current bruising, and muscle weakness with total cumulative corticosteroid dose quartiles
| Corticosteroid quartile | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | |||||||||
| Analysis | OR | OR | 95%CI | OR | 95% CI | OR | 95% CI | p trend | ||||
| All fracture | UV | 1.0 | 1.5 | 1.8 | 1.9 | |||||||
| MV | 1.0 | 1.96 | 0.95 to 4.0 | 2.13 | 1.04 to 4.4 | 2.22 | 1.04 to 4.8 | 0.04 | ||||
| Vertebrae | UV | 1.0 | 1.0 | 3.3 | 4.4 | |||||||
| MV | 1.0 | 1.4 | 0.31 to 6.7 | 4 | 1.06 to 15 | 9.2 | 2.4 to 36 | <0.001 | ||||
| Ribs/sternum | UV | 1.0 | 5.6 | 5.5 | 3.8 | |||||||
| MV | 1.0 | 6.3 | 1.23 to 33 | 5.9 | 1.14 to 31 | 5.4 | 0.94 to 31 | 0.1 | ||||
| 2 or more fractures | UV | 1.0 | 1.2 | 1.8 | 2.5 | |||||||
| MV | 1.0 | 1.9 | 0.61 to 5.7 | 2.4 | 0.83 to 7.1 | 4.1 | 1.4 to 12 | <0.01 | ||||
| Cataract | UV | 1.0 | 0.7 | 2 | 1.6 | |||||||
| MV | 1.0 | 0.9 | 0.36 to 2.3 | 2.5 | 1.1 to 5.6 | 3.1 | 1.3 to 7.5 | 0.002 | ||||
| Bruising | UV | 1.0 | 1.5 | 2.8 | 4.2 | |||||||
| MV | 1.0 | 2.2 | 1.03 to 4.6 | 3.9 | 1.7 to 8.6 | 9.4 | 3.6 to 25 | <0.001 | ||||
| Muscle weakness | UV | 1.0 | 1.3 | 1.9 | 2.1 | |||||||
| MV | 1.0 | 1.5 | 0.79 to 3 | 2.5 | 1.2 to 5 | 3.3 | 1.5 to 7 | <0.001 | ||||
Odds ratios are given using multiple logistic regression analysis in relation to the first quartile in a univariate (UV) and multivariate (MV) analysis with 95% confidence intervals for the latter.