Table 3

Initial and annual change in lung function in patients with infrequent and frequent exacerbations

Starting valueAnnual change
PEF=peak expiratory flow; FEV1=forced expiratory volume in 1 second.
*p<0.05, ***p<0.001 annual rates of change between infrequent and frequent exacerbators.
Exacerbations (reported and unreported)<50% percentile, <2.92 per year> 50% percentile >2.92 per year
PEF (l/min)214232–0.72–2.94***
FEV1 (ml)893950–32.1–40.1*