Geometric mean values (CV%) for the area under the curve for biochemical markers of bone metabolism over 2 years expressed as % change from baseline
| BUD | BDP | Reference | |
| Serum osteocalcin | 132 (81) | 104 (71)5-151 | 141 (101) |
| Urinary deoxypyridinoline | 92 (34) | 105 (38)5-150 | 96 (29) |
| Urinary pyridinoline | 90 (30) | 101 (37)5-150 | 95 (27) |