Multivariate analysis using tumour cell MMP-9 and EGFR as separate variables and as a combined variable
Factor | Hazard ratio | p value |
MMP-9 and EGFR as separate variables: | ||
Chalkley count | ||
Lower tertiles | 1.00 | 0.002 |
Upper tertile | 1.97 (1.28–3.03) | |
Tumour cell MMP-9 expression | ||
Negative | 1.00 | 0.004 |
Positive | 1.91 (1.23–2.97) | |
Stage | ||
I | 1.00 | 0.01 |
II | 1.44 (0.87–2.40) | |
IIIa | 2.21 (1.31–3.74) | |
Grade | ||
Well/moderately differentiated | 1.00 | 0.05 |
Poorly differentiated | 1.52 (0.99–2.33) | |
MMP-9 and EGFR as combined variable: | ||
Tumour cell EGFR/MMP-9 | ||
Negative | 1.00 | <0.001 |
Positive | 2.22 (1.45–3.41) | |
Chalkley count | ||
Lower tertiles | 1.00 | 0.001 |
Upper tertile | 2.12 (1.38–3.25) | |
Stage | ||
I | 1.00 | 0.007 |
II | 1.35 (0.81–2.25) | |
IIIa | 2.29 (1.36–3.84) | |
Grade | ||
Well/moderately differentiated | 1.00 | 0.21 |
Poorly differentiated | 1.31 (0.86–2.01) |