Multivariate analysis using tumour cell MMP-9 and EGFR as separate variables and as a combined variable
| Factor | Hazard ratio | p value |
| MMP-9 and EGFR as separate variables: | ||
| Chalkley count | ||
| Lower tertiles | 1.00 | 0.002 |
| Upper tertile | 1.97 (1.28–3.03) | |
| Tumour cell MMP-9 expression | ||
| Negative | 1.00 | 0.004 |
| Positive | 1.91 (1.23–2.97) | |
| Stage | ||
| I | 1.00 | 0.01 |
| II | 1.44 (0.87–2.40) | |
| IIIa | 2.21 (1.31–3.74) | |
| Grade | ||
| Well/moderately differentiated | 1.00 | 0.05 |
| Poorly differentiated | 1.52 (0.99–2.33) | |
| MMP-9 and EGFR as combined variable: | ||
| Tumour cell EGFR/MMP-9 | ||
| Negative | 1.00 | <0.001 |
| Positive | 2.22 (1.45–3.41) | |
| Chalkley count | ||
| Lower tertiles | 1.00 | 0.001 |
| Upper tertile | 2.12 (1.38–3.25) | |
| Stage | ||
| I | 1.00 | 0.007 |
| II | 1.35 (0.81–2.25) | |
| IIIa | 2.29 (1.36–3.84) | |
| Grade | ||
| Well/moderately differentiated | 1.00 | 0.21 |
| Poorly differentiated | 1.31 (0.86–2.01) | |