Table 2

Differentiation of epithelioid mesothelioma from adenocarcinoma

Epithelioid mesothelioma Adenocarcinoma
Cytoplasm contains glycogen but no diastase resistant PAS positive materialGlycogen content is small. May contain diastase resistant PAS positive mucin
Alcian blue positive hyaluronic acid in glands on tumour cell surfaceNo hyaluronic acid within or on tumour cells
CEA, Leu M1, Ber Ep4, and AUA1 negativeCEA, Leu M1, Ber Ep4, and AUA1 positive
Calretinin (positive nuclear staining2-150), cytokeratin 5/6 and thrombomodulin positiveCalretinin (negative nuclear staining2-150), cytokeratin 5/6 and thrombomodulin negative
  • 2-150 Calretinin stains the cytoplasm of both mesothelioma and adenocarcinoma.