Table 1

Summary of four randomised controlled trials of lung protection ventilation strategies in ARDS. Information on total patient entry to the studies, treatment modes and outcomes are shown

StudyNo of centresTotal patient entryConventional limbProtection limbControl mortalityIntervention mortalityp value
Brochard (1998)16 25 (worldwide)116 with ARDSTV ⩾10 ml/kg, normal Paco 2 TV <10 ml/kg, plateau pressure <25 cm H2O37.9%46.6%0.38
Stewart (1998)17 8 (Canada)120 high risk ventilated patientsTV 10–15 ml/kg, peak inspiratory pressure ⩽50 cm H2OTV <8 ml/kg, peak inspiratory pressure ⩽30 cm H2O47%50%0.72
Amato (1998)18 1 (Brazil) 53 with ARDSTV 12 ml/kg, Paco 2 4.7–5.1 kPa, least PEEP to maintain Pao 2 TV <6 ml/kg, PEEP >LIP on P/V curve peak pressure <20 cm H2O above PEEP71%38%<0.001
ARDS Network (2000)1 10 (North America)861 with ARDS12 ml/kg predicted body weight, plateau airway pressure ⩽50 cm H2O6 ml/kg predicted body weight, plateau airway pressure ⩽30 cm H2O39.8%31.0%0.007