Table 3

Cytokine production by alveolar macrophages (AM), divided retrospectively according to subjects' development of lung disease after stem cell transplantation (SCT)

	AM obtained before SCT (B1)
Cytokine	No post-SCT lung disease (n=22)	Post-SCT lung disease (n=10)	Significance	No post-SCT lung disease (n=19)	Post-SCT lung disease (n=5)	Significance
TNFα	1.9 (1.0–4.6)	7.9 (1.1–8.4)	p = 0.01 ^3-150	1.9 (0.31–3.3)	4.6 (2.2–9.0)	p = 0.07
GM-CSF	0.21 (0.07–0.79)	5.2 (0.72–8.3)	p = 0.006^†	0.11 (0.06–0.32)	1.2 (0.74–9.1)	p = 0.01^3-154
IL-1β	0.18 (0.07–0.91)	0.95 (0.15–2.2)	p = 0.06	0.18 (0.01–0.43)	0.13 (0.06–1.4)	p = 0.6
IL-6	0.10 (0.02–0.29)	0.46 (0.13–1.23)	p = 0.049^3-152	0.07 (0.04–0.13)	0.13 (0.06–2.1)	p = 0.2
IL-8	417 (204–533)	460 (298–805)	p = 0.3	172 (90–334)	355 (238–777)	p = 0.2

Values are medians (interquartile range) in ng/10⁶AM.
↵3-150 Median difference 3.4 (95% confidence interval (CI) 0.08 to 7.0). ^† Median difference 4.4 (95% CI 0.47 to 7.5).
↵3-152 Median difference 0.3 (95% CI 0.0002 to 0.92).
↵3-154 Median difference 1.1 (95% CI 0.11 to 5.8).