Quantitative changes in TGFβ1 and TGFβ3 gene expression in fibrotic human lung
Diagnosis | Histology | TGFβ1 | TGFβ3 |
SSc | Cellular | ↑ | ↓ |
SSc | Fibrotic | ↑ | → |
SSc | Fibrotic | → | → |
SSc | Fibrotic | → | – |
SSc | Cellular | → | → |
CFA | Fibrotic | → | → |
CFA | Fibrotic | – | – |
CFA | Mixed | ↑ | ↑ |
TGFβ1 gene expression was increased in three of the eight biopsy specimens while TGFβ3 gene expression was enhanced in only one.
SSc = systemic sclerosis; CFA = cryptogenic fibrosing alveolitis; ↑ = increased gene expression; ↓ = decreased; → = unchanged compared with control human lung tissue; – = not detected.