Table 2

Quantitative changes in TGFβ1 and TGFβ3 gene expression in fibrotic human lung

Diagnosis Histology TGFβ1 TGFβ3
SScCellular↑↓
SScFibrotic↑→
SScFibrotic→→
SScFibrotic→–
SScCellular→→
CFAFibrotic→→
CFAFibrotic––
CFAMixed↑↑

  • TGFβ1 gene expression was increased in three of the eight biopsy specimens while TGFβ3 gene expression was enhanced in only one.

  • SSc = systemic sclerosis; CFA = cryptogenic fibrosing alveolitis; ↑ = increased gene expression; ↓ = decreased; → = unchanged compared with control human lung tissue; – = not detected.