Subjects with post-transplant lung disease and/or relevant respiratory histories: clinical details and cytokine production status
| High cytokine production?2-150 | ||||
|---|---|---|---|---|
| Subject no | Post-transplant lung disease (days after SCT) | Respiratory history (time before B1) | TNFα | GM-CSF |
| 6 | Hypoxia, collapsed middle lobe (day 7) | Asthma, inhaled corticosteroids, recent mild exacerbation (3 weeks) | Yes | Yes |
| 7 | Pulmonary oedema, then pneumonia,Stenotrophomonas maltophila isolated; fatal (day 14) | Current smoker | Yes | Yes |
| 9 | Pseudomonas aeruginosa pneumonia, adult respiratory distress syndrome; fatal (day 10) | Chest infection (5 months) | Yes | Yes |
| 10 | Pneumonia,Candida albicans in BAL fluid (day 18) | None | Yes | Yes |
| 12 | None | Cough, green sputum (1 week) | No | No |
| 19 | Hypoxia, right basal consolidation (day 18) | Current smoker; pneumonia (2 years) | No | Yes |
| 21 | Pseudomonas aeruginosa pneumonia (day 10) | None | No | No |
| 22 | Breathlessness, fever, perihilar radiographic opacification (day 166) | Current smoker | Yes | Yes |
| 24 | Cough, fever, bibasal radiographic opacification (day 68) | Chest infection (13 months) | No | No |
| 28 | Cough, hypoxia, patchy radiographic opacification (day 0) | Dry cough (2 weeks) | Yes | Yes |
| 30 | None | Current smoker | No | Yes |
| 36 | None | Asthma, low dose inhaled steroids | No | No |
| 40 | None | Self-limiting dry cough (1 week) | No | No |
| 45 | None | Untreated childhood TB, abnormal chest radiograph | No | No |
| 47 | None | Current smoker | No | No |
| 49 | Fever, hypoxia, bibasal consolidation (day 13) | Pneumonia (5 months) | NA | NA |
| 52 | Hypoxia, diffuse radiographic opacification, recovery with corticosteroids (day 7) | Current smoker | No | No |
| 54 | None | Pulmonary vasculitis (3 years, recurrent at 9 months) | No | No |
↵2-150 Pre-SCT (B1) AM cytokine production: TNFα >7 ng/106AM, GM-CSF >2 ng/106AM.
NA = not available.