Table 4

Hormone replacement therapy (HRT) and risk of asthma and asthma-like symptoms in postmenopausal women

Predictors Asthma
(n=188)
Wheezing
(n=718)
Cough at exertion (n=433) Asthma medication (n=182)
Age (per 1 year)1.01 (0.99 to 1.03)0.99 (0.98 to 1.01)0.99 (0.99 to 1.01)1.02 (0.99 to 1.04)
BMI (kg/m2)
 <201.01.01.01.0
 20–251.02 (0.72 to 1.42)1.59 (1.31 to 1.93)1.17 (0.93 to 1.47)0.94 (0.67 to 1.32)
 >250.95 (0.61 to 1.47)2.13 (1.67 to 2.71)1.12 (0.83 to 1.51)0.87 (0.55 to 1.36)
Familial disposition to asthma (yes)3.16 (2.32 to 4.29)1.51 (1.24 to 1.84)1.21 (0.96 to 1.54)2.10 (1.53 to 2.89)
Education (years)
 >101.01.01.01.0
 7–101.22 (0.82 to 1.80)1.58 (1.27 to 1.97)1.59 (1.22 to 2.06)1.53 (1.03 to 2.28)
 <71.26 (0.82 to 1.94)1.34 (1.04 to 1.71)1.17 (0.86 to 1.60)1.37 (0.87 to 2.16)
Smoking:
 Never smoker1.01.01.01.0
 Ex-smoker2.16 (1.39 to 3.36)1.79 (1.37 to 2.32)1.56 (1.14 to 2.14)1.89 (1.21 to 2.97)
 Current smoker1.99 (1.32 to 3.00)4.26 (3.39 to 5.35)2.51 (1.91 to 3.29)2.06 (1.37 to 3.09)
HRT
 No1.01.01.01.0
 Yes1.42 (0.95 to 2.12)1.29 (1.02 to 1.64)1.34 (1.01 to 1.77)1.45 (0.97 to 2.18)
  • Odds ratios derived from multiple logistic regression with 95% CI in parentheses.