Mean (SD) forced expiratory volume in one second (FEV1) in litres on the three test days before and after the morning dose, at reaching a methacholine induced decrease in FEV1 of ⩾30%, at 3 and 30 minutes after salbutamol inhalation, and at 30 minutes after additional ipratropium bromide inhalation
| Pre-dose | Post-dose (baseline) | After methacholine (t = 0 min) |
After salbutamol (t = 3 min) |
After salbutamol (t = 30 min) | After additional ipratropium (t = 60 min) | |
| Formoterol (n=17) | 2.82 (0.72) | 2.99 (0.74) | 1.73 (0.52) | 1.94 (0.54)2-150 | 2.50 (0.71)2-150 | 2.90 (0.75) |
| Salmeterol (n=16) | 2.80 (0.69) | 2.98 (0.73) | 1.83 (0.56) | 2.00 (0.54)2-150 | 2.57 (0.65)2-150 | 2.94 (0.77) |
| Placebo (n=16) | 2.65 (0.67) | 2.67 (0.65) | 1.68 (0.46) | 2.10 (0.56) | 2.68 (0.67) | 2.94 (0.75) |
↵2-150 p<0.05 compared with placebo (significance only tested at 3 and 30 minutes).