Table 1

Underlying immunosuppressed condition and clinical characteristics of the 200 patients studied

HSCT Haematological malignancies Solid organ transplantation CIS Total
No. (%)53 (27%)68 (34%)52 (26%)27 (13%)200
Mean (SD) age (years)40 (12)54 (17)52 (16)60 (14)50 (17)
M/F33/2036/3243/913/14125/75
Neutropenia, n (%)21 (40%)28 (41%)3 (6%)1 (2%)53 (27%)
Mean (SD) APACHE II score18 (7)19 (8)20 (8)20 (8)19 (8)
Mean (SD) Pao 2/Fio 2 at inclusion269 (102)266 (95)221 (126)222 (113)249 (109)
Mechanical ventilation requirement, n (%)24 (45%)23 (34%)33 (63%)15 (56%)95 (47%)
Mortality, n (%)26 (49%)21 (31%)20 (38%)14 (52%)81 (40%)
  • HSCT = haematopoietic stem cell transplantation; CIS = chronic immunosuppressive treatment; APACHE II = Acute Physiology and Chronic Health Evaluation II score at admission.

  • Underlying diseases: chronic obstructive pulmonary disease (n=6), scleroderma (n=3), idiopathic pulmonary fibrosis (n=4), systemic vasculitis (n=3), rheumatoid arthritis (n=2), glomerulonephritis (n=2), and one each of systemic lupus erythematosus, relapsing polychondritis, dermatomyositis, mixed cryoglobulinaemia, Good-Pasteur syndrome, Beçhet syndrome, and primary biliary cirrhosis.

  • Neutropenia defined as a neutrophil count <1 × 109cells/l.