Table 2

Frequency of IL1RN/IL1B haplotypes in the study groups estimated using the expectation-maximisation (EM) algorithm25

Haplotype Fast decline (n=545) No decline (n=582) Odds ratio for fast decline (95% CI) p value (fast v no decline)
IL1RN A1/IL1B –511C0.510.550.8 (0.7 to 1.1)0.0005
IL1RN A2/IL1B –511C0.140.101.4 (1.0 to 2.1)
IL1RN A3/IL1B –511C0.010.030.5 (0.2 to 1.2)
IL1RN A1/IL1B –511T0.200.141.5 (1.1 to 2.1)
IL1RN A2/IL1B –511T0.140.180.7 (0.5 to 0.9)
IL1RN A3/IL1B –511T0.0106.5 (0.8 to 53.9)