Table 1

Inhalation schemes used for AMP challenge

		Study period 1995^1-150		Study period 1999^1-151
No inhalations (quadrupling doses)	No inhalations (doubling doses)	Concentration (mg/ml)	Cumulative dose (mg)	Concentration (mg/ml)	Cumulative dose (mg)
4	4	Saline	0	Saline	0
4	4	0.39	0.01	0.625	0.02
–	1	1.56	0.03	2.5	0.04
3	2	1.56	0.06	2.5	0.07
–	1	6.25	0.11	10	0.14
3	2	6.25	0.23	10	0.29
–	1	25	0.45	40	0.58
3	2	25	0.90	40	1.15
–	1	100	1.80	160	2.30
3	2	100	3.61	160	4.61
–	2	200	7.22	320	9.21
6	4	200	14.43	320	18.43
8	8	200	28.86	320	36.86

↵1-150 Study period 1995: nebuliser output 4.10 μl/s, inhalation time 2.2 seconds.
↵1-151 Study period 1999: nebuliser output 3.60 μl/s, inhalation time 2.0 seconds.