Table 1

De novo production of sulfidoleukotrienes (SLT) in patients with positive and negative oral provocation test (OPT) to aspirin

SLT (pg/ml)
OPT positive1-150 OPT negative1-150
C5a (10–7 M)n = 18n = 66
 Mean692117
 Median58379
 Min–max45–20100–549
p<0.0001
PAF (10–5M)n = 8n = 32
 Mean37156
 Median30045
 Min–max141–6470–198
p<0.0001
fMLP (10–6 M)n = 8n = 32
 Mean444123
 Median58284
 Min–max11–8480–647
p<0.01
  • PAF = platelet activating factor; fMLP = f-Met-Leu-Phe.

  • 1-150 Randomly selected patients with a history of adverse skin reaction to aspirin.