Table 1

Interaction of drugs with the immune system

Specific interactions
Immune reaction to the drug itself (“real” drug allergy)Penicillins, sulphonamides
Induction of an autoimmune response d-penicillamine, procainamide
Non-specific interactions
IgE (type 1)-like symptoms without evidence for sensitisation (= pseudoallergy)Acetylsalicylic acid
Interference with immune cell activation, signal transduction, cytokine productionCyclosporin A, thalidomide