Table 2

Bronchial inflammation according to exacerbation frequency (all patients)

MPO (units/ml)Elastase (nM)LTB4 (nM)IL-8
(nM)
SLPI
(μM)
Sol:serum albumin ratio (%)
Frequent (n=12)0.41 (0.31–0.59)0.00 (0.00–9.05)3.48 (1.6–5.7)3.1 (0.9–6.8)2.9 (1.9–6.0)0.35 (0.30–0.93)
Infrequent (n=28)0.37 (0.14–0.66)0.00 (0.00–7.33)4.5 (1.9–7.1)3.8 (1.0–6.9)4.4 (3.2–5.5)0.59 (0.28–1.19)
  • MPO = myeloperoxidase; LTB4 = leukotriene B4; IL-8 = interleukin 8; SLPI = secretory leukoprotease inhibitor.

  • Frequent exacerbators had suffered from ⩾3 exacerbations in the previous 12 months; infrequent exacerbators from ⩽2 exacerbations.

  • The concentrations of the inflammatory mediators are recorded as median (IQR). There were no significant differences between the frequent and infrequent exacerbators (p>0.05).