Baseline data, change in eNO (ΔeNO, parts per billion) and change in serum ascorbic acid (ΔVit C, μg/ml) following placebo or active (500 mg ascorbic acid bd) oral supplementation (n=20)
| Placebo exposure | Ascorbic acid exposure | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subject no | Age | Sex | FEV1(% predicted) | Baseline eNO (ppb) | ΔeNO (ppb) | Baseline Vit C (μg/ml) | ΔVit C (μg/ml) | Baseline eNO (ppb) | ΔeNO (ppb) | Baseline Vit C (μg/ml) | ΔVit C (μg/ml) | |
| 1 | 50 | F | 92 | 4.3 | 0.1 | 12.4 | 0.9 | 2.9 | 0.8 | 11 | 11.1 | |
| 2 | 36 | F | 85 | 6.2 | 0.7 | 11.0 | 0.1 | 4.5 | 4 | 11.7 | 7.5 | |
| 3 | 20 | M | 100 | 7.1 | –0.2 | 11.6 | –0.6 | 5.6 | 0.1 | 11.3 | 11.9 | |
| 4 | 24 | M | 101 | 12.3 | –3.7 | 11.9 | 2.2 | 4.9 | 2.6 | 15 | 5.3 | |
| 5 | 47 | F | 94 | 3.4 | 1.0 | 14.3 | –1.3 | 3.2 | 0.2 | 15.4 | 3.2 | |
| 6 | 35 | F | 84 | 11.4 | –5.3 | 11.0 | 7.4 | –0.3 | 13.4 | 5.1 | ||
| 7 | 39 | F | 103 | 11.9 | –2.3 | 15.1 | –0.8 | 9.8 | 0.3 | 13.4 | 11.9 | |
| 8 | 29 | F | 87 | 7.9 | –0.3 | 9.4 | 1.7 | 8.2 | –1.7 | 11.8 | 1.8 | |
| 9 | 38 | F | 92 | 8.8 | –1.4 | 9.2 | 0.4 | 11.4 | –1.2 | 10.1 | 12.7 | |
| 10 | 41 | F | 93 | 9.2 | –3.2 | 16.3 | –3.3 | 7.3 | 0.3 | 12.6 | 8.1 | |
| 11 | 35 | F | 112 | 5.4 | –1.9 | 14.8 | –1.3 | 3.2 | 0.8 | 15.8 | 1.8 | |
| 12 | 25 | F | 80 | 2.9 | 2.1 | 9.7 | 2.9 | 6.3 | –1 | 11.9 | 4.2 | |
| 13 | 28 | F | 105 | 5.8 | –0.5 | 11.7 | –3.3 | 7.2 | 0.1 | 4.6 | 22 | |
| 14 | 27 | F | 96 | 3 | 1.4 | 9.9 | 2.9 | 6.5 | 1.8 | 12.5 | 6.8 | |
| 15 | 31 | M | 96 | 5.4 | 2.3 | 13.3 | –1 | 5.3 | 3.4 | 11.1 | 6.6 | |
| 16 | 28 | M | 94 | 6.6 | 0.5 | 9.3 | 0.4 | 9.5 | –0.2 | 10.1 | 3.4 | |
| 17 | 25 | F | 86 | 12.4 | –3.9 | 18.8 | –1.1 | 10.4 | 2.3 | 14.7 | 8.5 | |
| 18 | 30 | M | 81 | 6.8 | –0.6 | 12.7 | 0.4 | 7.5 | –4.1 | 12.3 | 8.9 | |
| 19 | 43 | M | 92 | 6.3 | –0.6 | 1.1 | 0.3 | 5.4 | –0.6 | 3.8 | 5.3 | |
| 20 | 47 | F | 92 | 4.1 | 2.1 | 10.8 | 0.9 | 7 | –1.8 | 11.4 | 2.5 | |
| Mean (95% CI) | 33.9 | 93.2 | 7.1 | –0.7 (–1.7 to 0.3) | 11.7 | 0 (–0.8 to 0.8) | 6.7 | 0.3 (–0.6 to 1.2) | 11.7 | 7.42-150 (5.1 to 9.7) | ||
The serum ascorbic acid concentration following placebo was unavailable for one subject.
↵2-150 p<0.01 compared with placebo.