Table 1

Frequencies of TGF-β1polymorphisms

TGF-β1 polymorphisms Controls (n = 107)CF patients (n = 171)
+869 (codon 10) +915 (codon 25)
Allele frequencies
TAny139  (65%)224  (66%)
CAny75 (35%)118 (34%)
AnyG193 (90%)319 (93%)
AnyC21 (10%)23 (7%)
Genotype frequencies
T/T1-150 44 (41%)67 (39%)
T/C51 (48%)90 (53%)
C/C12 (11%)14 (8%)
G/G1-150 87 (81%)149 (87%)
G/C19 (18%)21 (12%)
C/C1 (1%)1 (1%)
T/TG/G44 (41%)66 (39%)
T/CG/G38 (36%)72 (42%)
C/CG/G5 (5%)11 (6%)
T/TG/C0 (0%)1 (0%)
T/CG/C13 (12%)17 (10%)
C/CG/C6 (6%)3 (2%)
T/TC/C 0 (0%)0 (0%)
T/CC/C0 (0%)1 (0%)
C/CC/C1 (1%)0 (0%)
  • 1-150 TGF-β1 high producer genotypes5 6; all others are TGF-β1 low producer genotypes.