Characteristics of 48 patients on mouth/nasal intermittent positive pressure ventilation (M/NIPPV)
| Diagnosis | Poliomyelitis | Duchenne's muscular dystrophy | Other myopathies | Motor neurone disease | Peripheral neuropathy | Multiple sclerosis | Kyphoscoliosis | S/P lobectomy/ thoracoplasty for TB |
| No. of patients (M/F) | 20 (6/14) | 15 (15/0) | 2 (1/1) | 2 (0/2) | 1 (1/0) | 2 (1/1) | 5 (1/4) | 1 (0/1) |
| Age when treatment started | 48.1 (12.6) | 20.3 (5.0) | 22 (15.6) | 43.5 (19.1) | 41 | 46.5 (3.5) | 44.8 (9.0) | 48 |
| Height (cm) | 166.8 (11.7) | 172.7 (11.6) | 165.1 (10.8) | 152.4 (3.6) | 182.9 | 160 (0) | 158.0 (16.0) | 165.1 |
| Weight (kg) | 60.6 (14.9) | 48.0 (15.1) | 32.5 (8.7) | 55.7 (14.5) | 50.5 | 95.9 (39.2) | 40.3 (10.7) | 63.2 |
| FVC (ml; % predicted) | ||||||||
| a | 1134 (417); 34 (12)% | 600 (219); 14 (5)% | 775 (106); 18 (7)% | 613 (159); 25 (12)% | 1100; 22% | 1150 (71); 38 (1)% | 690 (143.2); 20 (3)% | 1200; 41% |
| b | 1219 (417); 37 (14)% | 533 (379); 11 (7)% | 600 (141); 13 (3)% | 850 (212); 34 (17)% | 800; 16% | 1480 (962); 47 (30)% | 690 (167.3); 20 (5)% | 1100; 33% |
| Pco 2 (mm Hg) | ||||||||
| a | 51.7 (15.2) | 49.7 (7.5) | 48.0 (5.7) | 54.0 (8.5) | 38 | 57.5 (40.3) | 49.2 (7.2) | 50 |
| b | 45.1 (10.4)3-151 | 46.7 (8.5) | 47.0 (9.9) | 30.5 (3.5) | 40 | 54.0 (14.1) | 52.2 (12.4) | 36 |
| Time on non-invasive ventilation (months) | 38 (32) | 22 (22) | 41 (24) | 58 (57) | 5 | 17 (10) | 30 (21) | 32 |
| Gain or decline in FVC | ||||||||
| ml/year | 90 (225) | −60 (244) | −66 (49) | 104 (112) | −720 | 501 (921) | −18 (117) | −38 |
| % predicted/year | 3.6 (8.2) | −2.3 (5.9) | −1.3 (0.5) | 4.7 (5.6) | −14.4 | 14.5 (29.0) | −0.36 (3.1) | −3.0 |
| No. of patients eventually needing tracheostomy | 1 | 10 | 1 | 0 | 0 | 0 | 0 | 0 |
| No. of deaths | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Values are mean (SD) unless otherwise stated.
a = before ventilation; b = near end of period on ventilation; FVC = forced vital capacity; TB = tuberculosis; Pco 2= carbon dioxide tension.
↵3-151 Significantly different from pre-ventilation Pco 2, p<0.01 (pairedt test).